ACAD8

Across TCGA pan-cancer cohorts, ACAD8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ACAD8 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ACAD8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ACAD8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where ACAD8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.975	0.371	.002	25	view →
CCRCC	OS	Quartile	All	1.000	0.840	.014	16	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.890	.028	12	view →
LUAD	OS	Tertile	II,III,IV	0.836	0.331	.042	2	view →
LSCC	OS	Median	All	0.928	0.834	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ACAD8–PDAC (OS)

Open the PDAC breakdown →