ACAD8

Across TCGA patient cohorts, ACAD8 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAD8-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR_pY1068. Each is linked with ACAD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAD8-to-partner and partner-to-ACAD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ACAD8-low versus ACAD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAD8→partner) and Y-score (partner→ACAD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.399	+1.604	.030	.010	3	2
UCEC	14-3-3_beta →	-0.071	-2.673	.022	.005	3	1
UCEC	EGFR_pY1068 →	-0.220	-1.201	.004	.028	3	1
UCEC	eIF4E →	+0.181	+2.584	.005	.001	3	1
UCEC	eIF4G →	+0.297	+2.999	.002	<.001	3	1
UCEC	A-Raf_pS299 →	-0.096	-1.847	.009	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by ACAD8 expression — UCEC

Explore this box plot interactively →