ACAD11

Across TCGA pan-cancer cohorts, ACAD11 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ACAD11 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ACAD11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACAD11 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where ACAD11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.328	0.949	.024	19	view →
LSCC	OS	Median	III,IV	0.878	0.417	.009	12	view →
CCRCC	DFS	Quartile	II,III,IV	0.887	0.198	.024	8	view →
PDAC	DFS	Median	IV	0.741	0.214	.017	8	view →
LUAD	OS	Median	II,III,IV	0.786	0.499	.034	6	view →
GBM	OS	Median	All	0.265	0.454	.010	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ACAD11–HNSC (DFS)

Open the HNSC breakdown →