ACAD11

Across TCGA patient cohorts, ACAD11 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAD11-associated genes across cancer lineages are Ku80, S6_pS240_S244, and eIF4G. Each is linked with ACAD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAD11-to-partner and partner-to-ACAD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ACAD11-low versus ACAD11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAD11→partner) and Y-score (partner→ACAD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.214	+2.676	.015	<.001	3	2
UCEC	S6_pS240_S244 →	+0.411	+2.169	.006	.003	3	2
UCEC	eIF4G →	+0.244	+2.459	.036	.019	3	1
UCEC	ER-alpha_pS118 →	+0.302	+2.000	.024	.030	3	1
UCEC	INPP4B →	-0.321	-2.156	.008	.003	3	1
UCEC	JNK2 →	+0.194	+1.765	.009	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Ku80 by ACAD11 expression — UCEC

Explore this box plot interactively →