ACACA

Across TCGA patient cohorts, ACACA protein abundance is significantly associated with the RNA expression of many other genes, with 11,616 significant associations in total. OV shows the largest number of these associations.

The most reproducible ACACA-associated genes across cancer lineages are DHCR24, TNFSF12, and PIGW. Each is linked with ACACA in more than 6 cancer types. Because this analysis shows association rather than direction, both ACACA-to-partner and partner-to-ACACA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACACA versus DHCR24 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACACA→partner) and Y-score (partner→ACACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DHCR24 →	+1.238	+0.645	<.001	<.001	3	7
OV	TNFSF12 →	-0.573	-0.251	<.001	<.001	3	6
COAD	PIGW →	+0.718	+0.265	<.001	<.001	3	6
COAD	DHRS11 →	+0.493	+0.183	<.001	<.001	3	6
HNSC	SCD →	+1.426	+0.498	<.001	<.001	3	6
HNSC	ATP5MC1 →	+0.679	+0.263	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,616 associations by consensus.

ACACA vs DHCR24 — BRCA

Explore this scatter interactively →