ACACA

Across TCGA patient cohorts, ACACA mutation is significantly associated with the RNA expression of many other genes, with 5,462 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACACA-associated genes across cancer lineages are SKA1, MCAT, and ETNK2. Each is linked with ACACA in more than 5 cancer types. Because this analysis shows association rather than direction, both ACACA-to-partner and partner-to-ACACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by ACACA-low versus ACACA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACACA→partner) and Y-score (partner→ACACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.715	+1.757	<.001	<.001	3	6
UCEC	MCAT →	+0.317	+2.212	<.001	<.001	3	5
UCEC	ETNK2 →	-0.459	-2.241	<.001	<.001	3	5
SKCM	TFIP11 →	+0.309	+1.877	.005	<.001	3	4
COAD	ECHS1 →	+0.440	+3.807	<.001	<.001	2	5
UCEC	TIPIN →	+0.488	+1.905	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,462 associations by consensus.

SKA1 by ACACA expression — UCEC

Explore this box plot interactively →