ACACA

Across TCGA patient cohorts, ACACA mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACACA-associated genes across cancer lineages are Caspase-7-cleavedD198, Rad50, and 4E-BP1. Each is linked with ACACA in more than 4 cancer types. Because this analysis shows association rather than direction, both ACACA-to-partner and partner-to-ACACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ACACA-low versus ACACA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACACA→partner) and Y-score (partner→ACACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.883	+2.321	.004	.033	3	5
COAD	Rad50 →	-0.315	-2.296	<.001	.033	3	4
COAD	4E-BP1 →	+0.248	+1.593	.003	.043	3	4
SKCM	eEF2 →	+0.370	+2.338	.006	.017	3	4
UCEC	GAPDH →	+0.379	+1.736	.005	.005	3	4
UCEC	Cyclin-B1 →	+0.578	+2.459	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Caspase-7-cleavedD198 by ACACA expression — COAD

Explore this box plot interactively →