ACACA

Across TCGA cell cohorts, ACACA mutation is significantly associated with the RNA expression of many other genes, with 1,930 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACACA-associated genes across cancer lineages are FCER2, FOXR1, and PPP6R2. Each is linked with ACACA in more than 2 cancer types. Because this analysis shows association rather than direction, both ACACA-to-partner and partner-to-ACACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER2 grouped by ACACA-low versus ACACA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACACA→partner) and Y-score (partner→ACACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FCER2 →	+0.053	+3.865	<.001	<.001	3	3
URINARY_TRACT	FOXR1 →	+0.681	+4.044	.003	.001	3	2
LARGE_INTESTINE	PPP6R2 →	+0.578	+3.459	.001	.001	3	2
LARGE_INTESTINE	SCO1 →	+0.648	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	SLC25A39 →	+0.382	+3.257	.001	.002	3	2
LARGE_INTESTINE	FEM1A →	+0.675	+2.364	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,930 associations by consensus.

FCER2 by ACACA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →