ACACA

Across TCGA cell cohorts, ACACA mutation is significantly associated with the mutation status of many other genes, with 6,432 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACACA-associated genes across cancer lineages are PREX1, SYMPK, and CDH23. Each is linked with ACACA in more than 5 cancer types. Because this analysis shows association rather than direction, both ACACA-to-partner and partner-to-ACACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREX1 grouped by ACACA-low versus ACACA-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACACA→partner) and Y-score (partner→ACACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PREX1 →	+2.882	+2.882	.005	.005	1	6
LUNG_SCLC	SYMPK →	+4.562	+3.329	.003	.003	1	6
KIDNEY	CDH23 →	+3.201	+4.426	.001	.001	1	5
BLOOD_Lymphoma	ZMYND8 →	+3.922	+3.247	.004	.004	1	5
BLOOD_Lymphoma	UBR5 →	+3.752	+3.409	<.001	<.001	1	5
OVARY	KIAA1549 →	+2.882	+3.247	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,432 associations by consensus.

PREX1 by ACACA expression — OVARY

Explore this box plot interactively →