ABTB1

Across TCGA pan-cancer cohorts, ABTB1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ABTB1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ABTB1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ABTB1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where ABTB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.628	0.167	.006	18	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.304	.006	12	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.662	.017	11	view →
LUAD	OS	Quartile	All	0.930	0.425	.017	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ABTB1–PDAC (OS)

Open the PDAC breakdown →