ABTB1

Across TCGA cell cohorts, ABTB1 mutation is significantly associated with the drug of many other genes, with 47 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABTB1-associated genes across cancer lineages are Camptothecin, Nutlin-3a (-), and Rucaparib. Each is linked with ABTB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABTB1-to-partner and partner-to-ABTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Camptothecin grouped by ABTB1-low versus ABTB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABTB1→partner) and Y-score (partner→ABTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Camptothecin →	+0.629	+2.868	.023	.022	3	1
LARGE_INTESTINE	Nutlin-3a (-) →	+0.872	+2.868	.011	.022	3	1
LARGE_INTESTINE	Rucaparib →	+0.393	+2.710	.012	.043	3	1
LARGE_INTESTINE	Topotecan →	+0.503	+2.871	.038	.021	3	1
LARGE_INTESTINE	N29087-69-1 →	+0.358	+2.655	.030	.044	3	1
LARGE_INTESTINE	CX-5461 →	+0.675	+2.652	.021	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Camptothecin by ABTB1 expression — LARGE_INTESTINE

Explore this box plot interactively →