ABT1

Across TCGA patient cohorts, ABT1 mutation is significantly associated with the RNA expression of many other genes, with 448 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABT1-associated genes across cancer lineages are RNU6-1127P, KRT8P6, and MIR4477A. Each is linked with ABT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABT1-to-partner and partner-to-ABT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1127P grouped by ABT1-low versus ABT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABT1→partner) and Y-score (partner→ABT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1127P →	+0.260	+4.399	.006	.006	3	2
COAD	KRT8P6 →	+0.093	+2.984	<.001	.009	3	2
COAD	MIR4477A →	+0.247	+4.821	<.001	.003	3	2
UCEC	RPS3AP30 →	+0.070	+2.603	.006	.003	3	2
BLCA	RNA5SP503 →	+0.254	+5.444	<.001	.002	3	2
SKCM	MIR4650-2 →	+0.627	+5.328	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 448 associations by consensus.

RNU6-1127P by ABT1 expression — COAD

Explore this box plot interactively →