ABT1

Across TCGA patient cohorts, ABT1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABT1-associated genes across cancer lineages are eIF4E, MEK1, and mTOR_pS2448. Each is linked with ABT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABT1-to-partner and partner-to-ABT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ABT1-low versus ABT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABT1→partner) and Y-score (partner→ABT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.211	+2.321	.046	.035	3	1
UCEC	MEK1 →	+0.600	+3.459	.001	.005	3	1
UCEC	mTOR_pS2448 →	-0.218	-3.150	.003	.019	3	1
UCEC	Notch1 →	+0.191	+2.321	.006	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.539	-3.169	.016	.019	3	1
UCEC	p62 Lck ligand →	+0.645	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by ABT1 expression — UCEC

Explore this box plot interactively →