ABRAXAS2

Across TCGA patient cohorts, ABRAXAS2 mutation is significantly associated with the RNA expression of many other genes, with 3,342 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABRAXAS2-associated genes across cancer lineages are ESS2, CINP, and NUTF2. Each is linked with ABRAXAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABRAXAS2-to-partner and partner-to-ABRAXAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESS2 grouped by ABRAXAS2-low versus ABRAXAS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABRAXAS2→partner) and Y-score (partner→ABRAXAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ESS2 →	+0.282	+2.839	.003	.001	3	2
UCEC	CINP →	+0.261	+2.732	.004	.003	3	2
UCEC	NUTF2 →	+0.372	+1.880	.001	.005	3	2
UCEC	HMOX2 →	+0.344	+1.869	.004	.005	3	2
UCEC	YAP1P1 →	+0.125	+1.880	.003	.005	3	2
BLCA	MTND5P27 →	+0.020	+5.040	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,342 associations by consensus.

ESS2 by ABRAXAS2 expression — UCEC

Explore this box plot interactively →