ABRAXAS1

Across TCGA patient cohorts, ABRAXAS1 mutation is significantly associated with the RNA expression of many other genes, with 1,575 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABRAXAS1-associated genes across cancer lineages are CCL5, CCL18, and RPL34P3. Each is linked with ABRAXAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABRAXAS1-to-partner and partner-to-ABRAXAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL5 grouped by ABRAXAS1-low versus ABRAXAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABRAXAS1→partner) and Y-score (partner→ABRAXAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL5 →	+1.264	+4.000	<.001	<.001	3	2
UCEC	CCL18 →	+1.046	+2.230	.006	.006	3	2
HNSC	RPL34P3 →	+0.207	+4.505	<.001	.009	3	2
COAD	TEX29 →	+0.458	+3.352	<.001	.005	3	2
UCEC	SKA1 →	+0.647	+3.828	<.001	<.001	3	2
UCEC	PANK4 →	+0.326	+2.638	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,575 associations by consensus.

CCL5 by ABRAXAS1 expression — UCEC

Explore this box plot interactively →