ABRAXAS1

Across TCGA cell cohorts, ABRAXAS1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ABRAXAS1-associated genes across cancer lineages are XAGE5, OR1L1, and IQCF2. Each is linked with ABRAXAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABRAXAS1-to-partner and partner-to-ABRAXAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by ABRAXAS1-low versus ABRAXAS1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABRAXAS1→partner) and Y-score (partner→ABRAXAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	XAGE5 →	+0.245	+5.196	<.001	.005	3	1
OVARY	OR1L1 →	+0.036	+5.196	<.001	.005	3	1
OVARY	IQCF2 →	+0.055	+5.196	<.001	.005	3	1
OVARY	ODF4 →	+0.042	+5.196	<.001	.005	3	1
OVARY	OR13C8 →	+0.033	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

XAGE5 by ABRAXAS1 expression — OVARY

Explore this box plot interactively →