ABR

Across TCGA patient cohorts, ABR mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABR-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and Rad50. Each is linked with ABR in more than 2 cancer types. Because this analysis shows association rather than direction, both ABR-to-partner and partner-to-ABR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ABR-low versus ABR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABR→partner) and Y-score (partner→ABR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.494	+2.815	<.001	.036	3	3
UCEC	eEF2 →	+0.289	+1.678	.006	.019	3	3
UCEC	Rad50 →	-0.246	-1.986	<.001	.008	3	3
BRCA	Notch1 →	+0.196	+2.814	.041	.037	3	2
COAD	GAPDH →	+0.650	+2.815	.019	.036	3	2
COAD	Cyclin-E1 →	+0.279	+2.815	.043	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by ABR expression — COAD

Explore this box plot interactively →