ABR

Across TCGA cell cohorts, ABR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,567 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ABR-associated GO terms across cancer lineages are Actin filament depolymerization, Negative regulation of small GTPase mediated signal transduction, and Protein depolymerization. Each is linked with ABR in more than 13 cancer types. Because this analysis shows association rather than direction, both ABR-to-partner and partner-to-ABR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by ABR-low versus ABR-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABR→partner) and Y-score (partner→ABR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Actin filament depolymerization →	+0.168	+1.251	<.001	<.001	3	14
SKIN	Negative regulation of small GTPase mediated signal transduction →	+0.082	+1.211	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Protein depolymerization →	+0.124	+1.900	.003	.006	3	12
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.060	+0.863	.002	.005	2	12
BLOOD_Leukemia	Peptidyl-serine phosphorylation →	+0.051	+1.342	<.001	<.001	3	11
KIDNEY	MAPK cascade →	+0.049	+0.973	.005	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,567 associations by consensus.

Actin filament depolymerization by ABR expression — SKIN

Explore this box plot interactively →