ABR

Across TCGA cell cohorts, ABR mutation is significantly associated with the RNA expression of many other genes, with 344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABR-associated genes across cancer lineages are GALR3, OR4F6, and OR10D3. Each is linked with ABR in more than 1 cancer types. Because this analysis shows association rather than direction, both ABR-to-partner and partner-to-ABR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALR3 grouped by ABR-low versus ABR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABR→partner) and Y-score (partner→ABR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GALR3 →	+0.071	+3.628	.005	<.001	3	2
URINARY_TRACT	OR4F6 →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	OR10D3 →	+0.107	+4.087	.002	.009	3	1
URINARY_TRACT	TRIM49C →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	DCDC2C →	+0.129	+4.217	<.001	.005	3	1
BLOOD_Leukemia	INSM2 →	+0.155	+3.769	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 344 associations by consensus.

GALR3 by ABR expression — LARGE_INTESTINE

Explore this box plot interactively →