ABO

Across TCGA patient cohorts, ABO mutation is significantly associated with the RNA expression of many other genes, with 625 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABO-associated genes across cancer lineages are NPM1P38, RN7SL660P, and TTC30B. Each is linked with ABO in more than 1 cancer types. Because this analysis shows association rather than direction, both ABO-to-partner and partner-to-ABO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPM1P38 grouped by ABO-low versus ABO-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABO→partner) and Y-score (partner→ABO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NPM1P38 →	+0.242	+3.468	<.001	.008	3	2
COAD	RN7SL660P →	+0.374	+3.245	.006	.005	3	2
SKCM	TTC30B →	-0.801	-3.440	<.001	.005	3	2
UCEC	RNA5SP325 →	+0.901	+2.126	<.001	.003	3	2
UCEC	CFL1P4 →	+0.418	+2.233	.005	.006	3	2
UCEC	RNA5SP113 →	+0.353	+3.003	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 625 associations by consensus.

NPM1P38 by ABO expression — COAD

Explore this box plot interactively →