ABO

Across TCGA patient cohorts, ABO mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABO-associated genes across cancer lineages are PCNA, 14-3-3_beta, and EGFR_pY1068. Each is linked with ABO in more than 1 cancer types. Because this analysis shows association rather than direction, both ABO-to-partner and partner-to-ABO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ABO-low versus ABO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABO→partner) and Y-score (partner→ABO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.208	+2.584	.038	.011	3	2
UCEC	14-3-3_beta →	-0.122	-2.973	.009	.035	3	1
UCEC	EGFR_pY1068 →	-0.310	-2.584	.007	.011	3	1
UCEC	MEK1 →	+0.366	+2.321	.031	.034	3	1
UCEC	Notch1 →	+0.229	+3.183	<.001	.009	3	1
UCEC	PDCD4 →	-0.605	-2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PCNA by ABO expression — UCEC

Explore this box plot interactively →