ABO

Across TCGA cell cohorts, ABO RNA expression is significantly associated with the go_rna of many other GO terms, with 3,711 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABO-associated GO terms across cancer lineages are Cellular response to steroid hormone stimulus, Regulation of potassium ion import, and Response to steroid hormone. Each is linked with ABO in more than 9 cancer types. Because this analysis shows association rather than direction, both ABO-to-partner and partner-to-ABO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to steroid hormone stimulus grouped by ABO-low versus ABO-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABO→partner) and Y-score (partner→ABO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cellular response to steroid hormone stimulus →	+0.065	+3.133	.001	<.001	3	10
LUNG_NSCLC_LUAD	Regulation of potassium ion import →	+0.195	+1.767	<.001	<.001	3	9
OESOPHAGUS	Response to steroid hormone →	+0.115	+3.280	<.001	<.001	3	9
OESOPHAGUS	Regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.096	+2.228	.009	.004	3	9
KIDNEY	Positive regulation of nephron tubule epithelial cell differentiation →	+0.930	+1.511	.007	.006	3	9
PANCREAS	Serotonin secretion →	+1.240	+2.033	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,711 associations by consensus.

Cellular response to steroid hormone stimulus by ABO expression — OESOPHAGUS

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