ABL2

Across TCGA patient cohorts, ABL2 mutation is significantly associated with the RNA expression of many other genes, with 4,156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABL2-associated genes across cancer lineages are UFD1, SNORD115-21, and RPA1. Each is linked with ABL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABL2-to-partner and partner-to-ABL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UFD1 grouped by ABL2-low versus ABL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABL2→partner) and Y-score (partner→ABL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UFD1 →	+0.420	+1.901	<.001	<.001	3	4
BRCA	SNORD115-21 →	+0.742	+5.800	<.001	.003	3	3
UCEC	RPA1 →	+0.467	+1.955	<.001	<.001	3	3
LUAD	NEIL1 →	-0.721	-3.411	.003	.005	3	3
LUAD	LSP1P3 →	+0.246	+2.022	<.001	.009	3	3
LUAD	IFFO2 →	-0.648	-2.871	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,156 associations by consensus.

UFD1 by ABL2 expression — UCEC

Explore this box plot interactively →