ABL2

Across TCGA patient cohorts, ABL2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABL2-associated genes across cancer lineages are PAI-1, ASNS, and Cyclin-B1. Each is linked with ABL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABL2-to-partner and partner-to-ABL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by ABL2-low versus ABL2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABL2→partner) and Y-score (partner→ABL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PAI-1 →	+0.800	+3.169	.019	.018	2	4
UCEC	ASNS →	+0.362	+2.392	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.594	+2.584	<.001	<.001	3	3
UCEC	ERK2 →	+0.174	+2.087	.001	.004	3	2
UCEC	FoxM1 →	+0.159	+0.999	.032	.042	3	2
UCEC	mTOR_pS2448 →	-0.114	-1.717	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

PAI-1 by ABL2 expression — LUAD

Explore this box plot interactively →