ABL2

Across TCGA cell cohorts, ABL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,361 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABL2-associated GO terms across cancer lineages are Negative regulation of Rho protein signal transduction, Positive regulation of establishment of T cell polarity, and Regulation of hippo signaling. Each is linked with ABL2 in more than 19 cancer types. Because this analysis shows association rather than direction, both ABL2-to-partner and partner-to-ABL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Rho protein signal transduction grouped by ABL2-low versus ABL2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABL2→partner) and Y-score (partner→ABL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of Rho protein signal transduction →	+0.175	+1.594	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Positive regulation of establishment of T cell polarity →	+0.273	+1.653	<.001	<.001	3	18
STOMACH	Regulation of hippo signaling →	+0.092	+2.021	.002	<.001	3	17
BONE	Regulation of focal adhesion assembly →	+0.123	+1.180	<.001	<.001	3	16
BONE	Regulation of protein K48-linked ubiquitination →	+0.204	+1.779	<.001	<.001	3	16
BONE	Regulation of cell-substrate junction assembly →	+0.123	+1.180	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,361 associations by consensus.

Negative regulation of Rho protein signal transduction by ABL2 expression — LIVER

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