ABL1

Across TCGA patient cohorts, ABL1 mutation is significantly associated with the RNA expression of many other genes, with 5,448 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABL1-associated genes across cancer lineages are UHRF1, TTLL12, and TRIM16L. Each is linked with ABL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABL1-to-partner and partner-to-ABL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by ABL1-low versus ABL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABL1→partner) and Y-score (partner→ABL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.927	+2.688	<.001	<.001	3	3
UCEC	TTLL12 →	+0.458	+2.467	.001	<.001	3	3
UCEC	TRIM16L →	+0.678	+3.108	<.001	<.001	3	3
UCEC	LRRC59 →	+0.605	+2.110	<.001	<.001	3	3
UCEC	TUBA1B →	+0.800	+1.680	<.001	<.001	3	3
UCEC	DGCR6L →	+0.421	+2.099	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,448 associations by consensus.

UHRF1 by ABL1 expression — UCEC

Explore this box plot interactively →