ABL1

Across TCGA patient cohorts, ABL1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABL1-associated genes across cancer lineages are INPP4B, eIF4E, and ERK2. Each is linked with ABL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABL1-to-partner and partner-to-ABL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ABL1-low versus ABL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABL1→partner) and Y-score (partner→ABL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.481	-3.321	.001	.009	3	3
COAD	eIF4E →	+0.224	+2.334	.001	.018	3	2
COAD	ERK2 →	+0.213	+3.169	.005	.018	3	2
COAD	Rad50 →	-0.307	-2.674	.001	.005	3	2
COAD	TSC1 →	-0.447	-3.898	<.001	<.001	3	2
COAD	ASNS →	+0.452	+2.123	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

INPP4B by ABL1 expression — COAD

Explore this box plot interactively →