ABI3

Across TCGA pan-cancer cohorts, ABI3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ABI3 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ABI3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ABI3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where ABI3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.828	0.518	.006	30	view →
UCEC	DFS	Tertile	II,III,IV	0.430	0.904	.026	18	view →
HNSC	DFS	Quartile	All	0.640	0.892	.008	14	view →
PDAC	OS	Tertile	All	0.763	0.480	.008	7	view →
LUAD	DFS	Quartile	All	1.000	0.916	.008	6	view →
GBM	OS	Quartile	All	0.298	0.516	.039	2	view →
LSCC	DFS	Median	II,III,IV	0.573	0.813	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ABI3–CCRCC (DFS)

Open the CCRCC breakdown →