ABI3

Across TCGA patient cohorts, ABI3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABI3-associated genes across cancer lineages are EGFR_pY1068, PCNA, and Caspase-8. Each is linked with ABI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABI3-to-partner and partner-to-ABI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ABI3-low versus ABI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABI3→partner) and Y-score (partner→ABI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.266	-2.321	.035	.035	3	1
UCEC	PCNA →	+0.241	+3.000	.026	.036	3	1
UCEC	Caspase-8 →	-0.256	-3.321	.042	.010	3	1
UCEC	ERK2 →	+0.310	+3.459	.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

EGFR_pY1068 by ABI3 expression — UCEC

Explore this box plot interactively →