ABI3

Across TCGA cell cohorts, ABI3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,096 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ABI3-associated GO terms across cancer lineages are Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, Regulation of response to nutrient levels, and Bone mineralization involved in bone maturation. Each is linked with ABI3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ABI3-to-partner and partner-to-ABI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction grouped by ABI3-low versus ABI3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABI3→partner) and Y-score (partner→ABI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.033	+1.051	<.001	.007	3	6
CNS	Regulation of response to nutrient levels →	-0.071	-0.549	.002	.005	3	5
BONE	Bone mineralization involved in bone maturation →	+1.581	+1.584	<.001	<.001	3	4
BONE	Nuclear transport →	+0.065	+1.211	.003	.009	2	5
BONE	Nucleocytoplasmic transport →	+0.065	+1.211	.003	.009	2	5
BLOOD_Myeloma	Formate metabolic process →	+0.105	+0.548	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,096 associations by consensus.

Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction by ABI3 expression — BLOOD_Lymphoma

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