Across TCGA pan-cancer cohorts, ABI1P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ABI1P1’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ABI1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ABI1P1 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.
BLCA and KIRP are the cancer types where ABI1P1 tumor–normal differential expression is most reproducible.