ABHD5

Across TCGA pan-cancer cohorts, ABHD5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ABHD5 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ABHD5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ABHD5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where ABHD5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.968	0.777	.008	47	view →
HNSC	OS	Tertile	IV	0.978	0.782	.004	30	view →
PDAC	OS	Median	II,III,IV	0.301	0.636	.007	10	view →
LUAD	DFS	Quartile	II,III,IV	0.367	1.000	.022	5	view →
GBM	OS	Tertile	All	0.304	0.564	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ABHD5–CCRCC (OS)

Open the CCRCC breakdown →