ABHD3

Across TCGA cell cohorts, ABHD3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABHD3-associated genes across cancer lineages are CHRNA2, DEFA4, and TBC1D21. Each is linked with ABHD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD3-to-partner and partner-to-ABHD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNA2 grouped by ABHD3-low versus ABHD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD3→partner) and Y-score (partner→ABHD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHRNA2 →	+0.095	+3.453	<.001	.009	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.023	+3.658	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CHRNA2 by ABHD3 expression — LARGE_INTESTINE

Explore this box plot interactively →