ABHD15

Across TCGA pan-cancer cohorts, ABHD15 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ABHD15 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ABHD15 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ABHD15 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

UVM, LGG, and HNSC are the cancer types where ABHD15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.412	0.763	<.001	117	view →
LGG	DFS	Median	All	0.645	0.839	<.001	54	view →
HNSC	OS	Tertile	All	0.272	0.551	<.001	41	view →
KIRC	DFS	Median	II,III,IV	0.788	0.517	.001	30	view →
BRCA	DFS	Tertile	III,IV	0.867	0.703	.004	26	view →
LAML	DFS	Quartile	All	0.359	0.688	.011	24	view →
READ	DFS	Quartile	II,III,IV	0.795	0.267	.014	16	view →
LUAD	DFS	Tertile	All	0.268	0.488	.022	15	view →
PAAD	OS	Tertile	All	0.414	0.155	.010	9	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	9	view →
PRAD	DFS	Median	All	0.914	0.855	.031	8	view →
ACC	DFS	Median	II,III,IV	0.251	0.785	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ABHD15–UVM (OS)

Open the UVM breakdown →