ABHD12

Across TCGA pan-cancer cohorts, ABHD12 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ABHD12 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ABHD12 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ABHD12 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where ABHD12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.827	0.361	.005	29	view →
CCRCC	OS	Median	III,IV	0.626	0.930	.003	26	view →
LUAD	OS	Tertile	II,III,IV	0.361	0.908	.006	20	view →
PDAC	DFS	Quartile	All	0.293	0.516	.006	11	view →
COAD	DFS	Median	III,IV	0.890	1.000	.029	6	view →
GBM	DFS	Quartile	All	0.780	0.616	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ABHD12–LSCC (DFS)

Open the LSCC breakdown →