ABHD11

Across TCGA patient cohorts, ABHD11 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABHD11-associated genes across cancer lineages are ATM, EGFR_pY1068, and ERK2. Each is linked with ABHD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD11-to-partner and partner-to-ABHD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ABHD11-low versus ABHD11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD11→partner) and Y-score (partner→ABHD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.544	-1.906	.002	.016	3	2
UCEC	EGFR_pY1068 →	-0.208	-1.906	.039	.016	3	1
UCEC	ERK2 →	+0.196	+2.115	.011	.017	3	1
UCEC	FOXO3a_pS318_S321 →	-0.124	-2.690	.013	.006	3	1
UCEC	mTOR_pS2448 →	-0.129	-2.308	.031	.033	3	1
UCEC	Notch1 →	+0.151	+2.472	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by ABHD11 expression — UCEC

Explore this box plot interactively →