ABHD10

Across TCGA pan-cancer cohorts, ABHD10 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ABHD10’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ABHD10 RNA is repressed in tumor relative to normal tissue. In most cancer types ABHD10 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and HNSC are the cancer types where ABHD10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABHD10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−0.769	<.001	10	view →
THCA	Male	III,IV	−0.852	<.001	9	view →
HNSC	All	III,IV	+0.679	<.001	8	view →
COAD	All	II,III,IV	+0.532	<.001	8	view →
KIRC	Male	All	−0.522	<.001	7	view →
BLCA	All	All	+0.654	.001	6	view →
STAD	All	II,III,IV	+0.613	<.001	6	view →
BRCA	Female	II,III,IV	+0.170	.017	6	view →
LUSC	All	II,III,IV	+0.582	<.001	5	view →
LIHC	Male	All	+0.426	<.001	5	view →
LUAD	Male	All	+0.423	<.001	4	view →
PRAD	All	All	+0.309	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ABHD10–KIRP

Open the KIRP breakdown →