ABCG5

Across TCGA cell cohorts, ABCG5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,151 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ABCG5-associated GO terms across cancer lineages are Negative regulation of intestinal absorption, Muscle organ development, and Microspike assembly. Each is linked with ABCG5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCG5-to-partner and partner-to-ABCG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of intestinal absorption grouped by ABCG5-low versus ABCG5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG5→partner) and Y-score (partner→ABCG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of intestinal absorption →	+0.158	+0.331	<.001	<.001	3	5
OVARY	Muscle organ development →	-0.041	-0.042	.002	.004	3	4
SKIN	Microspike assembly →	-0.622	-0.283	.002	<.001	3	4
LUNG_NSCLC_LUSC	Vacuole organization →	+0.044	+0.042	.001	.002	3	4
SOFT_TISSUE	Positive regulation of integrin biosynthetic process →	-0.893	-0.010	.008	.004	3	4
BONE	Ciliary neurotrophic factor-mediated signaling pathway →	-0.147	-0.013	.006	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,151 associations by consensus.

Negative regulation of intestinal absorption by ABCG5 expression — SKIN

Explore this box plot interactively →