ABCG5

Across TCGA cell cohorts, ABCG5 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCG5-associated genes across cancer lineages are SPATA31E1, STH, and MC3R. Each is linked with ABCG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCG5-to-partner and partner-to-ABCG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31E1 grouped by ABCG5-low versus ABCG5-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG5→partner) and Y-score (partner→ABCG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPATA31E1 →	+0.166	+4.906	<.001	.006	3	1
OESOPHAGUS	STH →	+0.076	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	MC3R →	+0.042	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	AKAP4 →	+0.010	+3.544	.001	.009	3	1
LUNG_NSCLC_LUAD	OR4N5 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	TMEM207 →	+0.125	+4.472	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

SPATA31E1 by ABCG5 expression — OESOPHAGUS

Explore this box plot interactively →