ABCG4

Across TCGA pan-cancer cohorts, ABCG4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ABCG4 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ABCG4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ABCG4 expression acts as an unfavorable survival marker.

KIRP, UCEC, and LGG are the cancer types where ABCG4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	III,IV	0.236	0.809	<.001	20	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SARC	DFS	Median	All	0.206	0.612	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ABCG4–KIRP (OS)

Open the KIRP breakdown →