ABCG2

Across TCGA pan-cancer cohorts, ABCG2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ABCG2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ABCG2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ABCG2 is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

LSCC, HNSC, and LUAD are the cancer types where ABCG2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCG2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	−1.102	<.001	8	view →
HNSC	All	IV	−1.095	<.001	8	view →
LUAD	Male	All	−0.701	<.001	5	view →
PDAC	All	III,IV	+0.433	.009	3	view →
CCRCC	Male	All	+0.332	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ABCG2–LSCC

Open the LSCC breakdown →