ABCG2

Across TCGA patient cohorts, ABCG2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCG2-associated genes across cancer lineages are mTOR_pS2448, PCNA, and PDCD4. Each is linked with ABCG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCG2-to-partner and partner-to-ABCG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ABCG2-low versus ABCG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG2→partner) and Y-score (partner→ABCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.136	-2.401	.005	.002	3	3
UCEC	PCNA →	+0.311	+2.643	<.001	<.001	3	2
UCEC	PDCD4 →	-0.565	-3.238	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.352	-1.492	<.001	.027	3	2
UCEC	TFRC →	+0.458	+1.392	.008	.019	3	2
UCEC	ASNS →	+0.294	+1.502	.013	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

mTOR_pS2448 by ABCG2 expression — UCEC

Explore this box plot interactively →