ABCG2

Across TCGA cell cohorts, ABCG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,239 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ABCG2-associated GO terms across cancer lineages are Biotin transport, Regulation of body fluid levels, and Positive regulation of sodium ion transmembrane transport. Each is linked with ABCG2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ABCG2-to-partner and partner-to-ABCG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Biotin transport grouped by ABCG2-low versus ABCG2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG2→partner) and Y-score (partner→ABCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Biotin transport →	-0.221	-0.638	<.001	<.001	3	8
BONE	Regulation of body fluid levels →	+0.076	+0.595	<.001	.001	3	8
BONE	Positive regulation of sodium ion transmembrane transport →	+0.227	+0.638	<.001	<.001	3	8
CNS	Positive regulation of tumor necrosis factor-mediated signaling pathway →	+0.113	+1.179	<.001	<.001	3	7
CNS	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.064	+1.046	<.001	<.001	3	7
KIDNEY	Intestinal cholesterol absorption →	+0.271	+1.024	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,239 associations by consensus.

Biotin transport by ABCG2 expression — BONE

Explore this box plot interactively →