ABCG2

Across TCGA cell cohorts, ABCG2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCG2-associated genes across cancer lineages are KRT85, MBD3L5, and POMC. Each is linked with ABCG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCG2-to-partner and partner-to-ABCG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT85 grouped by ABCG2-low versus ABCG2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG2→partner) and Y-score (partner→ABCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KRT85 →	+0.026	+4.807	<.001	.006	3	1
SKIN	MBD3L5 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	POMC →	+0.610	+3.257	<.001	.001	3	1
LARGE_INTESTINE	LCT →	+0.556	+3.464	<.001	.004	3	1
LARGE_INTESTINE	AKR1D1 →	+0.220	+2.651	.001	.007	3	1
LARGE_INTESTINE	SULT6B1 →	+0.024	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

KRT85 by ABCG2 expression — BLOOD_Myeloma

Explore this box plot interactively →