ABCF3

Across TCGA pan-cancer cohorts, ABCF3 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ABCF3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ABCF3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ABCF3 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where ABCF3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCF3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.255	<.001	11	view →
LSCC	Male	All	+0.768	<.001	9	view →
LUAD	Male	II,III,IV	+0.325	<.001	9	view →
COAD	Female	III,IV	+0.279	<.001	9	view →
CCRCC	Male	All	−0.157	<.001	6	view →
PDAC	Female	All	−0.256	.001	4	view →
OV	All	All	+0.432	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ABCF3–HNSC

Open the HNSC breakdown →