ABCF3

Across TCGA cell cohorts, ABCF3 mutation is significantly associated with the mutation status of many other genes, with 3,598 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCF3-associated genes across cancer lineages are SEMA4G, LGI4, and LRRC43. Each is linked with ABCF3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCF3-to-partner and partner-to-ABCF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMA4G grouped by ABCF3-low versus ABCF3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCF3→partner) and Y-score (partner→ABCF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SEMA4G →	+5.339	+4.772	.004	.004	1	5
LUNG_NSCLC_LUAD	LGI4 →	+4.339	+4.339	.009	.009	1	4
OVARY	LRRC43 →	+4.977	+4.415	.007	.007	1	4
SKIN	MAP4K4 →	+5.392	+4.824	.004	.004	1	4
OVARY	TNRC6C →	+3.240	+4.467	.004	.004	1	4
OVARY	MSH2 →	+3.977	+4.930	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,598 associations by consensus.

SEMA4G by ABCF3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →