ABCF2

Across TCGA patient cohorts, ABCF2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCF2-associated genes across cancer lineages are p62 Lck ligand, JNK2, and Ku80. Each is linked with ABCF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCF2-to-partner and partner-to-ABCF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ABCF2-low versus ABCF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCF2→partner) and Y-score (partner→ABCF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.440	+3.807	.002	<.001	3	2
UCEC	JNK2 →	+0.247	+2.700	.005	.006	3	1
UCEC	Ku80 →	+0.287	+2.713	.006	.003	3	1
UCEC	MEK1 →	+0.380	+2.000	.021	.032	3	1
UCEC	PCNA →	+0.296	+2.700	.002	.006	3	1
UCEC	Claudin-7 →	-0.667	-2.000	.003	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by ABCF2 expression — UCEC

Explore this box plot interactively →