ABCF2

Across TCGA cell cohorts, ABCF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,330 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ABCF2-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and DNA-templated transcription termination. Each is linked with ABCF2 in more than 16 cancer types. Because this analysis shows association rather than direction, both ABCF2-to-partner and partner-to-ABCF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by ABCF2-low versus ABCF2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCF2→partner) and Y-score (partner→ABCF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	rRNA 5'-end processing →	+0.152	+1.206	<.001	<.001	3	17
URINARY_TRACT	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.152	+1.206	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription termination →	+0.117	+1.064	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.145	+0.767	<.001	<.001	3	16
BLOOD_Myeloma	Maturation of SSU-rRNA →	+0.121	+0.999	<.001	<.001	3	15
OVARY	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.145	+0.960	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,330 associations by consensus.

rRNA 5'-end processing by ABCF2 expression — URINARY_TRACT

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