Across TCGA patient cohorts, ABCF1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCF1-associated genes across cancer lineages are A-Raf_pS299, PKC-delta_pS664, and Shc_pY317. Each is linked with ABCF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCF1-to-partner and partner-to-ABCF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCF1→partner) and Y-score (partner→ABCF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.177	-2.321	<.001	.033	3	2
UCEC	PKC-delta_pS664 →	-0.141	-3.459	.003	.005	3	2
UCEC	Shc_pY317 →	-0.200	-2.000	.001	.030	3	2
UCEC	ASNS →	+0.519	+2.115	<.001	.017	3	2
UCEC	ATM →	-0.718	-2.415	<.001	.003	3	2
UCEC	C-Raf →	+0.194	+1.906	<.001	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

ABCF1 survival (RNA) · tumor vs normal (RNA) · all ABCF1 data types