ABCD2

Across TCGA patient cohorts, ABCD2 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCD2-associated genes across cancer lineages are Snail, ERK2, and JNK_pT183_Y185. Each is linked with ABCD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCD2-to-partner and partner-to-ABCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Snail grouped by ABCD2-low versus ABCD2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD2→partner) and Y-score (partner→ABCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Snail →	-0.164	-3.446	.019	.005	3	3
SKCM	ERK2 →	+0.187	+2.321	.030	.006	3	2
COAD	JNK_pT183_Y185 →	-0.316	-2.321	.007	.033	3	2
UCEC	MEK1 →	+0.467	+3.273	<.001	<.001	3	2
COAD	p53 →	-0.379	-3.169	.009	.018	3	2
COAD	p62 Lck ligand →	+0.450	+3.000	.010	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Snail by ABCD2 expression — SKCM

Explore this box plot interactively →